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Staley, Jonathan P.
One or more keywords matched the following properties of Staley, Jonathan P.
PropertyValue
full name Jonathan P. Staley
keywords mammalian systems
keywords genome-wide studies
keywords splicing
keywords RNA Sequence
keywords Spliceosome
keywords Yeast Proteins
keywords snRNA
keywords Baker's Yeast
keywords Brewer's Yeast
label Staley, Jonathan P.
last name Staley
overview Our goal is to understand the mechanism and regulation of nuclear pre-mRNA splicing, an essential step in eukaryotic gene expression. Pre-mRNA splicing is catalyzed by a massive multimegadalton ribonucleoprotein machine called the spliceosome. Using the model organism S. cerevisiae as well as human cells, we apply a wide array of approaches, ranging from single molecule microscopy, biophysics, and chemical biology to biochemistry and cell biology to genetics and genomics to gain a deep understanding of how the spliceosome catalyzes and regulates pre-mRNA splicing, including in the context of transcription.
One or more keywords matched the following items that are connected to Staley, Jonathan P.
Item TypeName
Concept Alleles
Concept Amino Acid Sequence
Concept Base Sequence
Concept Binding Sites
Concept Genes, Dominant
Concept Genes, Lethal
Concept Molecular Sequence Data
Concept Nucleic Acid Conformation
Concept Magnetic Resonance Spectroscopy
Concept Solutions
Concept RNA Splicing
Concept Schizosaccharomyces
Concept Sulfanilic Acids
Concept Sequence Homology, Amino Acid
Concept Yeasts
Concept Trans-Splicing
Concept RNA Splice Sites
Concept Mutagenesis, Site-Directed
Concept Spliceosomes
Concept Alternative Splicing
Concept Protein Structure, Tertiary
Concept Ribonucleoprotein, U1 Small Nuclear
Concept Ribonucleoprotein, U4-U6 Small Nuclear
Concept Amino Acid Substitution
Concept Oligonucleotide Array Sequence Analysis
Concept RNA, Small Nucleolar
Concept Catalytic Domain
Concept Saccharomyces cerevisiae Proteins
Concept RNA, Double-Stranded
Concept Saccharomyces cerevisiae
Concept Structure-Activity Relationship
Concept Suppression, Genetic
Concept Substrate Specificity
Concept Genome, Fungal
Concept RNA, Small Untranslated
Concept Ribonucleoprotein, U5 Small Nuclear
Concept Transcriptome
Concept DNA, Single-Stranded
Concept Genes, Fungal
Concept Lod Score
Concept RNA, Small Nuclear
Concept Signal Transduction
Concept Ribonucleoproteins, Small Nuclear
Academic Article Mechanical devices of the spliceosome: motors, clocks, springs, and things.
Academic Article An RNA switch at the 5' splice site requires ATP and the DEAD box protein Prp28p.
Academic Article Specific alterations of U1-C protein or U1 small nuclear RNA can eliminate the requirement of Prp28p, an essential DEAD box splicing factor.
Academic Article Hanging on to the branch.
Academic Article The splicing factor Prp43p, a DEAH box ATPase, functions in ribosome biogenesis.
Academic Article DEAD on.
Academic Article U2 toggles iteratively between the stem IIa and stem IIc conformations to promote pre-mRNA splicing.
Academic Article Multiple functions for the invariant AGC triad of U6 snRNA.
Academic Article A role for ubiquitin in the spliceosome assembly pathway.
Academic Article Assembly of ribosomes and spliceosomes: complex ribonucleoprotein machines.
Academic Article Long-distance splicing.
Academic Article The EF-G-like GTPase Snu114p regulates spliceosome dynamics mediated by Brr2p, a DExD/H box ATPase.
Academic Article Evidence that U2/U6 helix I promotes both catalytic steps of pre-mRNA splicing and rearranges in between these steps.
Academic Article Exon ligation is proofread by the DExD/H-box ATPase Prp22p.
Academic Article Spliceosome discards intermediates via the DEAH box ATPase Prp43p.
Academic Article Staying on message: ensuring fidelity in pre-mRNA splicing.
Academic Article Spliceosome activation: U4 is the path, stem I is the goal, and Prp8 is the keeper. Let's cheer for the ATPase Brr2!
Academic Article Autosomal-dominant retinitis pigmentosa caused by a mutation in SNRNP200, a gene required for unwinding of U4/U6 snRNAs.
Academic Article Meiosis-induced alterations in transcript architecture and noncoding RNA expression in S. cerevisiae.
Academic Article The DEAH box ATPases Prp16 and Prp43 cooperate to proofread 5' splice site cleavage during pre-mRNA splicing.
Academic Article Complete folding of bovine pancreatic trypsin inhibitor with only a single disulfide bond.
Academic Article Intronic sequence elements impede exon ligation and trigger a discard pathway that yields functional telomerase RNA in fission yeast.
Academic Article A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation.
Academic Article Splicing fidelity: DEAD/H-box ATPases as molecular clocks.
Academic Article Role of a subdomain in the folding of bovine pancreatic trypsin inhibitor.
Academic Article RNA catalyses nuclear pre-mRNA splicing.
Academic Article The DExD/H-box ATPase Prp2p destabilizes and proofreads the catalytic RNA core of the spliceosome.
Academic Article Synthesis and incorporation of the phosphoramidite derivative of 2'-O-photocaged 3'-s-thioguanosine into oligoribonucleotides: substrate for probing the mechanism of RNA catalysis.
Academic Article Evidence for a group II intron-like catalytic triplex in the spliceosome.
Academic Article Knocking Down Snrnp200 Initiates Demorphogenesis of Rod Photoreceptors in Zebrafish.
Award or Honor Receipt Distinguished Investigator Award, Biological Sciences Division
Award or Honor Receipt Stephen F. Sener, M.D. - Research Scholar Award
Award or Honor Receipt David & Lucile Packard Fellowship in Science and Engineering
Academic Article Formation of a native-like subdomain in a partially folded intermediate of bovine pancreatic trypsin inhibitor.
Academic Article Sequencing of lariat termini in S. cerevisiae reveals 5' splice sites, branch points, and novel splicing events.
Academic Article Spliceosomal DEAH-Box ATPases Remodel Pre-mRNA to Activate Alternative Splice Sites.
Academic Article Reverse transcriptases lend a hand in splicing catalysis.
Academic Article Cancer therapies activate RIG-I-like receptor pathway through endogenous non-coding RNAs.
Academic Article Neoadjuvant androgen deprivation prior to transperineal prostate brachytherapy: smaller volumes, less morbidity.
Academic Article Specific Recognition of a Single-Stranded RNA Sequence by a Synthetic Antibody Fragment.
Academic Article The Evolutionarily-conserved Polyadenosine RNA Binding Protein, Nab2, Cooperates with Splicing Machinery to Regulate the Fate of pre-mRNA.
Academic Article Structure of the DEAH/RHA ATPase Prp43p bound to RNA implicates a pair of hairpins and motif Va in translocation along RNA.
Award or Honor Receipt Fellow
Academic Article Termination of pre-mRNA splicing requires that the ATPase and RNA unwindase Prp43p acts on the catalytic snRNA U6.
Academic Article Profiling lariat intermediates reveals genetic determinants of early and late co-transcriptional splicing.
Concept RNA Splicing Factors
Concept Splicing Factor U2AF
Academic Article The debranching enzyme Dbr1 regulates lariat turnover and intron splicing.
Academic Article Global impact of aberrant splicing on human gene expression levels.
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  • Yeast